【研究突破:特殊免疫细胞可让癌细胞休眠】

【研究突破:特殊免疫细胞可让癌细胞休眠】澳大利亚一研究团队在《自然》杂志发表的研究报告称,其发现了TRM免疫细胞如何让皮肤癌的癌细胞进入休眠状态的机制。研究人员借助小鼠黑色素瘤模型以及新的成像技术,以实时观察免疫细胞的运动,发现TRM细胞在抑制癌症进展和维持癌症免疫平衡上具有重要作用,并表示这有望为研究免疫治疗技术提供新的途径,以有效阻止肿瘤的生长。

The end of skin cancer? Breakthrough as Australian scientists discover a cell that can 'put melanoma tumours to sleep'

  • Scientists have made a breakthrough discovery regarding treatment of cancer
  • Research has uncovered special immune cells which put melanomas to sleep
  • Experts did not know how the tissue-resident memory T-cells worked until now  

Scientists have made a breakthrough discovery that could open up revolutionary treatments for skin cancer.

Research has uncovered that special immune cells have the power to put melanoma tumours 'to sleep', stopping them from spreading.

The tissue-resident memory T-cells have been used to fight cancer in the past but researchers did not know how they worked - until now.

Scientists have made a breakthrough discovery that could open up revolutionary treatments for skin cancer (special T cells pictured in green, melanoma cells in red and skin in blue)

Scientists have made a breakthrough discovery that could open up revolutionary treatments for skin cancer (special T cells pictured in green, melanoma cells in red and skin in blue)

Research carried out by scientists at Melbourne's Peter Dohety Institute and Telethon Kids Institute was published in Nature journal on Tuesday.

They discovered that the T-cells could be used to stop the growth of skin cancers.

Paper lead author Simone Park said the T-cells 'hold the cancer in check'.

'What we found was that the cells are capable of inducing a state of dormancy of the tumour, stopping the cancer cells without killing them,' Ms Park told Daily Mail Australia.

'These particular cells are very good at controlling melanoma long term.'

She said scientists monitored both melanoma and T-cells using fluorescent markers.

Researchers discovered that the T-cells could be used to stop the growth of skin cancers (special T cells pictured in green, melanoma cells in red and skin in blue)

Researchers discovered that the T-cells could be used to stop the growth of skin cancers (special T cells pictured in green, melanoma cells in red and skin in blue)

'We could watch in real time the T cells interacting with melanoma cells,' she said.

T-cells were removed from mice which had dormant melanomas, and once the cells were taken out then tumours then began to grow.

'We could identify melanoma cells that can't be seen with the naked eye,' Ms Park said.

'This mechanism hadn't been described before.'

Ms Park said she hoped the research breakthrough could lead to more improved treatments for melanoma.

'In the future, the broader effect could be how to better treat melanoma... and hopefully treat people much better than we are now,' she said.

In Australia, there are 14,000 new diagnoses of melanoma each year - and almost 2000 deaths from the skin cancer.

The nation has the second highest rate of melanoma in the world.

原文链接:https://www.dailymail.co.uk/news/article-6543745/Breakthrough-Australian-scientists-discover-cell-melanoma-tumours-sleep.html


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