#科技头条#【失忆恢复、记忆力提高再添新方法:科学家利用电脉冲提高记忆力】

#科技头条#【失忆恢复、记忆力提高再添新方法:科学家利用电脉冲提高记忆力】《神经工程杂志》近期的一份报告表示,人类海马体中有关记忆的神经编码被首次破解,填补缺失记忆再添新方法。研究者在14名志愿者的大脑中植入了电极,并让他们完成记忆任务,然后记录下记忆的电活动模式并解码,再精确地为每个志愿者提供到达海马体目标区域的电子脉冲,影响神经放电模式,从而改善记忆效果。在测试中,志愿者的记忆力提高了35%,失忆病人的病情也有所改善。

Electrical Pulses and Neural Code Boost Memory Storage

By artificially replicating the neural firing involved in correct memory formation, researchers improved memory by 35 percent

Looking at data on a screen after a successful implementation
Image: Wake Forest Baptist Medical Center

Researchers have figured out how to strengthen the storage of new memories in the human brain using electrical stimulation and neural patterns that were previously used to store other memories.

In case that sentence didn’t get stored properly in your own brain, we’ll say it another way: Scientists now have the power—using electrical impulses—to improve storage of new information in the human brain.

The report, published last week in the Journal of Neural Engineering, is the first to crack the neural codes linked to specific, individual memories in the human hippocampus, says Robert Hampson, a professor at Wake Forest Baptist Medical Center, who co-authored the report. The research is one of several approaches that could one day lead to “brain prostheses” to fill in for lost memory.

As complicated as manipulating a specific memory sounds, there’s also a simplicity to it. After all, neurons in the brain communicate via electrical impulses. The brain’s communication system can be hacked by feeding in artificially generated electrical messages, like tapping in Morse code [or like writing computer code].

In the new report, the researchers accomplished that on a highly targeted level. They focused on episodic memory: information that is new and useful for a short period of time, like where you parked your car, or where you put your keys. “Episodic memory is very sensitive,” says Hampson. “It’s easily damaged.”

A patient  is examined after a successful  implementation of a prosthetic system
Image:  Wake Forest Baptist Medical Center
A patient with electrodes implanted in her brain uses a touchscreen to identify familiar images in a series.

The study went like this: 14 volunteers, with electrodes implanted in their brains, performed a memory task similar to that involved in episodic memory. As they did this, the researchers recorded, in the brain’s hippocampus, the patterns of electrical activity associated with the storage of the memory. (The participants had already had the electrodes implanted for a separate epilepsy procedure.)

“We were able to get simultaneous recordings from anywhere from 10 to 60 neurons at a time,” says Hampson. Amazingly, even when a person’s memory is impaired, it is possible to identify the neural firing patterns that indicate correct memory formation, he says.

Then, using a multi-input, multi-output nonlinear mathematical model developed by bioengineers Theodore Berger and Dong Song at the University of Southern California in Los Angeles, they decoded those neural patterns and synthesized a code for correct memory storage. Berger’s team has previously used the model to decode animal memories.

With the neural code in hand, the team could then recreate it artificially. Volunteers were asked to perform a memory task, and as they did, the researchers fed electrical impulses, in a precise pattern customized for each volunteer, to the target area of the hippocampus, influencing the firing pattern of those neural circuits.

In other words: They recorded the brain activity associated with the storage of specific information, mathematically modeled and decoded that activity, and then wrote the code back into brain to make existing memory work better.

A patient takes a memory test post procedure
Image:  Wake Forest Baptist Medical Center
A patient completes a memory test for a new study that uses electrical impulses to improve retention of specific information.

With the electrical boost, volunteers’ memory performance improved by 35 percent, according to the report. The improvement was higher in patients who had experienced greater memory loss. Among the volunteers with good memory, there wasn’t much change, Hampson says.

Key to the success: the microelectrodes, which were designed to record the activity of single neurons. That, in combination with Berger’s mathematical model, which had been honed for coding memory patterns, enabled the project, Hampson says.

The study was funded by DARPA, the U.S. Department of Defense’s research arm, through its Restoring Active Memory, or RAM program. Through this program, the agency has been challenging neuroscientists to develop an implantable device that can mitigate memory loss in vets with traumatic brain injury.

In February another RAM awardee, Michael Kahana at the University of Pennsylvania, reported another advance in memory prostheses: His group identified brain states that signal when memory is predicted to fail, and designed stimulation that would promote the brain state associated with success. His group previously found that electrical stimulation should be delivered precisely when memory is predicted to fail, rather than when memory is operating efficiently.

https://spectrum.ieee.org/the-human-os/biomedical/devices/next-step-in-human-brain-prostheses


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