【科学家们发现艾滋病毒潜伏方式,治疗指日可待】

【科学家们发现艾滋病毒潜伏方式,治疗指日可待】很久以来,研究人员一直不解为何受HIV感染的细胞可以潜伏多年,但是,加利福尼亚大学的研究人员发现了其在血液中潜伏的方式,实验揭示了病毒是如何隐藏起来、防止抗病毒药物将其清除的。该实验的专家称,他们现在可以开始开发药物,杀死休眠细胞,从而将它们排除在潜伏期之外。

Scientists are one step closer to a HIV cure after discovering how it lurks in cells

  • Scientists say they've discovered one of the ways HIV lurks in the bloodstream
  • The discovery could bring medicine closer to a cure for the pernicious virus
  • The University of California team show how HIV-infected cells become 'latent'
  • They developed various treatments that nudge these cells out of their latency

A cure for HIV could be in the pipeline, scientists claim.

Experiments have today revealed exactly how the killer virus hides away, preventing antiviral drugs from flushing it out.

Researchers haven long been baffled as to why some infected cells can go dormant and evade detection for years.

But the new findings, made by University of California, San Francisco researchers, finally offer the medical community an answer.

They discovered the cells can spontaneously become 'latent' - or dormant - by refusing to make the virus like a normally infected cell.

The experts behind the trial, derived from 18 HIV patients, claim they can 'now start developing drugs' to allow the body to kill the dormant cells.

Scientists say they've discovered one of the ways HIV lurks in the bloodstream

There are currently no treatments that exist that can kill latent cells or stop them from reactivating in the future.

Scientists already understand the HIV life cycle.

Typically, the virus infects CD4 T cells, a type of immune cell, and uses the cell's DNA to produce viral RNA - which transports genetic messages for making proteins.

These new virus bodies then leave the cell to infect more.

However, the latency phase, in which an HIV-infected cell stops making the virus for a long period of time, has remained a mystery.

Because they are not reproducing the virus, they are difficult to target using current treatments. And they can be deadly when they become active.

 'We can't even separate out uninfected from infected cells, let alone latently infected cells,' said Dr Steven Yukl, from the University of California, San Francisco.

'Latently-infected cells are extremely rare - one in one million CD4 T cells - and we don't know how to identify them.'

Why they sometimes become active again is poorly understood. There are currently no treatments that can kill latent cells or stop them from reactivating.

To their surprise, they discovered bits and pieces of viral RNA, showing the virus was attempting to reproduce unsuccessfully

WHAT IS AN 'UNDETECTABLE VIRAL LOAD' OF HIV?

A person with HIV becomes 'undetectable' when treatment suppresses the virus to a level so low in their blood that it cannot be detected by measurements.

If a person is undetectable and stays on treatment, they cannot pass HIV on to a partner.

No study has ever shown HIV transmission from someone with an undetectable viral load.

To date, an undetectable load is almost always achieved with daily doses of antiretroviral drugs.

But a number of clinical trials - including PRO-140 by CytoDyn, which Charlie Sheen is involved in - hope to be developing treatments that could be administered on a weekly or fortnightly basis.

Roughly 30 percent of America's 1.2 million people with HIV have reached an undetectable viral load which underscores the need for expanded access to testing, treatment, and care.

For more information and resources, visit the Prevention Access Campaign website.

To try and understand how they work better, the San Francisco team performed a series of tests on the latent HIV-infected cells.

They discovered bits and pieces of viral RNA, showing the virus was attempting to reproduce unsuccessfully.

'It's not that the cells aren't making viral RNA, but that the RNA isn't finished,' Dr Yukl said.

Scientists said if the cells can be compelled to finish the transcription process then they will no longer be invisible to current treatments.

'Now we can start developing drugs that will make them finish the viral RNA, which can then be made into viral proteins so that the body can recognize and kill the infected cells,' Dr Yukl added.

The team have experimented with some treatments, and have variously succeeded in forcing the infected cells to complete some part of their viral RNA strands.

However, the search for a treatment that makes the virus reproduce fully is still a work in progress.

Dr Yukl believes this could lead to all new treatments for the virus and further minimise viral loads in sufferers.

'One of the nice things about knowing all these mechanisms is that we can look for new drugs or combinations and test how well they can overcome these transcription blocks,' he said.

'It provides a roadmap to design and evaluate new therapies.'

原文链接:http://www.dailymail.co.uk/health/article-5464459/Research-sheds-light-HIV-virus-hides-treatments.html#ixzz58zDDpd00

 


Comments are closed.



无觅相关文章插件