【斑马鱼细胞修复作用大:脊髓损伤不再是永久创伤】

【斑马鱼细胞修复作用大:脊髓损伤不再是永久创伤】爱丁堡研究人员发现斑马鱼在脊髓受伤后四周内可以恢复正常运动,原因是它的成纤维细胞能修复脊髓损伤,使其重新恢复运动能力。成纤维细胞能产生胶原蛋白12分子,促进受损的神经纤维再生。对于人和其他哺乳动物,脊髓损伤是永久性的,并导致不可逆转的瘫痪,该发现有助于治疗受损神经,有望帮助瘫痪患者重获运动能力。

Hope for a people with spinal cord injuries after scientists pinpoint key molecules in zebrafish that help them repair damaged nerves

  • Zebrafish regain full movement within four weeks of injury to their spinal cord
  • For people damage to the spinal cord is permanent and results in paralysis
  • Researchers have uncovered a 'vital mechanism' that helps nerves to regrow
  • Finding could restore vital connections between brain and muscles of the body

Zebrafish have the remarkable ability to regain full movement within four weeks of injury to their spinal cord (stock image)

HOW DOES IT WORK?

The Edinburgh researchers say they have found that after injury to the spinal cord in zebrafish, wound-healing cells called 'fibroblasts' move into the site of damage.

The fibroblasts produce a molecule called collagen 12, which changes the structure of the support matrix that surrounds nerve fibres.

This enables the damaged fibres to grow back across the wound site and restore the lost connections.

Scientists found that fibroblasts are instructed to make collagen 12 by a chemical signal called 'wnt'.

Understanding these signals could hold clues for therapies to help heal the spinal cord after injury.

High profile victims of such tragic accidents include the late Superman actor Christopher Reeve, who became a quadriplegic after being thrown from a horse during an equestrian competition in Virginia in 1995.

He was confined to a wheelchair and required a portable ventilator until his death nine years later.

Now, scientists at the University of Edinburgh's Centre for Neuroregeneration say they have pinpointed 'key molecules' that prompt damaged nerve fibres in zebrafish spinal cords to regenerate themselves.

The finding could pave the way for doctors to restore vital connections between the brain and muscles of the body lost after spinal cord injury in humans.

The Edinburgh researchers say they have found that after injury to the spinal cord in zebrafish, wound-healing cells called 'fibroblasts' move into the site of damage.

The fibroblasts produce a molecule called collagen 12, which changes the structure of the support matrix that surrounds nerve fibres.

This enables the damaged fibres to grow back across the wound site and restore the lost connections.

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High profile victims of such tragic accidents include the late Superman actor Christopher Reeve (left), who became a quadriplegic after being thrown from a horse during an equestrian competition in Virginia in 1995. Here he is pictured with his wife Dana Reeve (right)

The Scots scientists found that fibroblasts are instructed to make collagen 12 by a chemical signal called 'wnt'.

Understanding these signals could hold clues for therapies to help heal the spinal cord after injury.

'In people and other mammals, the matrix in the injury site blocks nerves from growing back after an injury', said Dr Thomas Becker of the Centre for Neuroregeneration at the University of Edinburgh.

'We have now pinpointed the signals that remove this roadblock in zebrafish, so that nerve cells can repair connections that are lost after damage to the spinal cord.'

The Edinburgh team will now try to establish whether triggering similar signals in other animals can help them to repair nerve connections damaged by spinal cord injuries.

The study was published in the scientific journal Nature Communications.

http://www.dailymail.co.uk/sciencetech/article-4727978/People-spinal-cord-injuries-walk-zebrafish-breakthrough.html


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