【青蛙鼻涕可以治感冒吗?】

【青蛙鼻涕可以治感冒吗?】近日,埃默里大学的科学家们测试了印度稀有青蛙的黏液,发现青蛙黏液含有强大的多肽,这种粘液有能力破坏人类流感病毒株。研究人员称,抗流感肽在疫苗不可用或在大型流感的情况下,可成为抵抗病毒的耐用药物。同时,从青蛙分泌的粘液中提取肽是相对容易的。http://www.dailymail.co.uk/health/article-4422446/Could-frog-snot-cure-flu.html

Could frog snot cure the flu? Scientists discover slimy mucus contains powerful peptides that destroy most strains of human influenza

  • Scientists at Emory University tested mucus from a rare Indian frog
  • They found the slime they secrete has the power to destroy strains of human flu

Practically all animals make a few anti-microbial host defence peptides as part of their innate immune systems.

Frogs have drawn the most attention as a source of peptides, because it's relatively easy to isolate the peptides from their mucus

Researchers from the Rajiv Gandhi Center for Biotechnology in Kerala, India, have been isolating peptides from their local frogs.

For the research, which appears in the journal Immunity, Dr Jacob and his colleagues screened 32 frog defence peptides against an influenza strain and found that four of them had flu-busting abilities.

He said: 'I was almost knocked off my chair. In the beginning, I thought that when you do drug discovery, you have to go through thousands of drug candidates, even a million, before you get one or two hits. And here we did 32 peptides, and we had four hits.'

Dr Jacob and his colleagues named one of the antiviral peptides they identified urumin, after a whip-like sword called 'urumi' used in southern India centuries ago.

When delivered intra-nasally, urumin protected unvaccinated mice against a lethal dose of some flu viruses.

Urumin was specific for H1 strains of flu, such as the 2009 pandemic strain, and was not effective against other current strains such as H3N2.

Developing antimicrobial peptides into effective drugs has been a challenge in the past, partly because enzymes in the body can break them down.

Dr Jacob's lab is now exploring ways to stabilise antiviral peptides such as urumin, as well as looking for frog-derived peptides that are active against other viruses like dengue and Zika.

原文链接:

http://www.dailymail.co.uk/health/article-4422446/Could-frog-snot-cure-flu.html

 

 


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