“神奇药丸”真能延长生命?科学家为你解答

【“神奇药丸”真能延长生命?科学家为你解答】这种称为雷帕霉素的特效药,是在复活节岛的土壤中发现的。目前,该药物已用于移植患者预防器官退化,还有望帮助治疗认知能力下降。在检测到它能够延长老鼠寿命后,华盛顿大学的科学家们开始测试其是否对狗狗也同样有效。初步试验结果令人震惊,仅仅几周后有些狗狗的心脏功能便得到改善。

Could this 'miracle drug' extend your life? First results of anti-ageing medical trial on dogs are ‘astonishing', says scientist
Rapamycin is a bacterial by-product discovered in soil at Easter Island
It is already used in transplant patients to prevent organ rejection
After finding it increases life of mice, anti-aging drug now tested on dogs
Study found dogs receiving the drug showed improved heart functionality

A ‘miracle drug’ found in the soil at Easter Island is believed to have qualities that could one day help humans live longer – and it may already be working for dogs.

Scientists from the University of Washington are testing the effects of a drug called rapamycin on dogs to see if it will slow down the aging process.

Researchers were shocked by results of the initial trials, finding that some dogs showed improved heart functionality after just a few weeks.

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The study is led by biologist Matt Kaeberlein and his colleague, Daniel Promislow.

According to Fusion, the researchers began clinical trials this year, expanding on earlier findings that rapamycin increases the lifespan of mice.

Rapamycin is a bacterial by-product discovered in the shadows of the island's famous statues and is named after Rapa Nui, the Polynesian name for Easter Island.

Dogs age very quickly compared to a human lifespan; most live between 10 and 13 years.

This allows researchers to study the entire aging process in a short amount of time.

The team recruited 40 dog-owners, who were each to give their pets three tablets of rapamycin a week, Fusion reports.

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After the researchers weeded out dogs with heart conditions and other medical factors, they were left with 24 middle-aged dogs, who would each receive low doses of the drug.

This continued over the course of 10 weeks, and the researchers took echocardiograms throughout to determine any changes in the animal’s heart function.

The team discovered that dogs receiving rapamycin showed improved heart functionality, or showed no change.

And, those who had come in with worse conditions initially saw the most improvement, Fusion reports.

Kaeberlein says the results are 'astonishing' and he was 'shocked' when he got the data.

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Rapamycin is already used in transplant patients to prevent organ rejection and several years ago, and scientists in the journal Neuroscience said it can improve learning and help treat cognitive decline.

In mice, it has been shown to extend the lives of mice by 13 per cent in females and nine per cent in males.

Now, the researchers say it may help dogs live longer as well.

‘It is almost certain that rapamycin can slow the effects of aging in dogs and people,’ Kaeberlein told Fusion.

‘The only question is whether it can slow aging with doses that don’t have significant side effects.’

Moving forward, the researchers plan to conduct further tests with the drugs that will span multiple years – and they hope it will be approved for humans in the next decade.

http://www.dailymail.co.uk/sciencetech/article-3577923/Could-miracle-drug-extend-life-results-anti-ageing-medical-trial-dogs-astonishing-says-scientist.html


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