#研究分享#【人类首次实现用DNA存储信息】

#研究分享##研究分享#【人类首次实现用DNA存储信息】法国的一个研究团队宣称,他们已成功将成功利用单体(某对染色体缺失一条的个体)合成一种聚合物以存储信息。整个过程由人工合成,时间持续一天,而信息解读可在5分钟完成。团队希望5年内产出几兆大小的产品,用于高附加值商品的条形码。http://www.looooker.com/archives/14032

众所周知,DNA存储信息的潜力无限。其所拥有的34亿碱基对可让人类在占用极小空间的情况下存贮海量信息。但是DNA技术的限制让研究人员需要发展一种廉价的方式。法国的一个研究团队宣称,他们已成功将成功利用单体(在遗传学上指控制相同性状的某对染色体缺失一条染色体的个体)合成一种聚合物以存储二进制信息。整个过程由人工合成,时间持续了一天,但研究人员称如果实现自动化将极大缩短合成的时间。而使用一台质谱仪将可在5分钟内把合成物的信息解读出来。人工聚合物在室温下可保存数月乃至几年的时间,团队希望产品在今后的3到5年内将能够实现存储几千至几兆字节的功能,用于高附加值产品的条形码。

Researchers have for the first time succeeded in recording a binary code on a synthetic polymer. Inspired by the capacity of DNA to retain an enormous amount of genetic information, a team from the Institut Charles Sadron de Strasbourg (CNRS) and the Institut de chimie radicalaire (CNRS/Aix Marseille Université) synthesized and read a multi-bit message on an artificial polymer. The results were published in Nature Communications on May 26, 2015.

With its 3.4 billion base pairs, human DNA can compile a tremendous amount of information in a tiny space. All of the information stored is expressed using four nitrogenous bases: A, T, G and C. Researchers had previously been able to use the sequencing of these veritable molecular building blocks to reproduce a binary code. However, the technical limits of DNA made it necessary to develop the first synthetic polymer -- cheaper, more malleable and able to store binary information. This has now been achieved for the first time by a team of French scientists from the CNRS and Aix-Marseille Université.

Instead of using the four nitrogenous bases of DNA, in this study the researchers used three monomers . Two of these monomers represent the binary code numbers 0 and 1, and can be used interchangeably during synthesis. A third nitroxide monomer was inserted between the bits in order to facilitate the writing and reading of the coded sequence.

A short binary message is synthesized by hand, monomer by monomer on a growing chain. The operation takes approximately a day, but should be quicker once automated. Decoding is done by sequencing, in the same way that DNA has been decoded for decades. A mass spectrometer thus takes less than five minutes to decipher the information -- a duration also destined to be reduced in the short term.

While sequencing systematically destroys the polymer, it is also possible to erase the code at any time and without reading it, by exposure to temperatures above 60ºC or to a laser. Researchers showed that at room temperature, the polymer can be conserved for a number of months, and could even last several years given the molecule's stability.

The team hopes to store messages of a few kilobytes or even megabytes within 3 to 5 years. This technique, patented by the CNRS, also makes it possible to develop molecular barcodes in the short term. Sequences could provide labeling that would be extremely difficult to falsify, ideal for high value-added products such as luxury goods and medicine. The use of monomers and secret codes, known only to the laboratory and the industrial partner, would make it very difficult to produce counterfeits.

文章来源:sciencedaily

http://www.sciencedaily.com/releases/2015/06/150604141624.htm


Comments are closed.



无觅相关文章插件